Trial subjects, are clinical trial volunteers.
When developing new drugs, hospitals or research institutions will find healthy people to participate in Phase I clinical trials, to determine whether the experimental drug is absolutely safe and whether it has any side effects.
Every medicine has its own side effects!
Normal people, after taking medicine, will metabolize it out of their body within a certain period of time, but there will always be a small amount of residue.
In other words, every trial subject is bearing a certain level of risk of drug residue.
Clinical trials are risky.
Therefore, hospitals or research institutions will provide volunteers with generous compensation, as well as taking care of their food and accommodation, and providing nutritional meals, etc.
It's a quick and easy way to make money.
Therefore, professional trial subjects emerged!
Shen Yan and Wu Hao are professional trial subjects.
The two of them became professional trial subjects for different reasons.
Shen Yan spends money lavishly and often consumes ahead of his income, leaving him heavily in debt.
Wu Hao, however, has a different story. It stems from his mother's death due to cancer.
He joined the trial subject industry to make a contribution to other patients, to hold up a protective umbrella for them!
Shen Yan and Wu Hao are good friends.
But their beliefs are different.
Shen Yan feels that being a trial subject is a precarious profession.
Your body could break down at any time.
The higher the salary, the more attractive it is.
To sacrifice your body without pay is just nonsense!
Wu Hao, however, is very noble.
He believes that professional trial subjects are the cornerstone of supporting clinical trials!
Every time he participates in a trial, he only wants to make a contribution to medicine.
...
July 1st.
Over a table filled with alcohol.
Shen Yan, having had a bit too much to drink, said loudly: "You're amazing, you're so high-minded! Out of ten thousand people in the trial subject industry, can there be one like you, Wu Hao?"
"I'm willing to take risks, to be a test subject for medicine!"
Wu Hao said with resolute determination.
Hearing these words.
Shen Yan shook his head.
He didn't say anything more.
He himself is terrified every time he participates in a trial.
He's afraid that he'll develop incurable aftereffects.
Shen Yan took a sip of alcohol and said with genuine emotion: "I'll do a few more trials, pay off my debts, and then return to a normal life."
"That's good!"
Wu Hao smiled and nodded.
The general public doesn't understand professional trial subjects, and even views them as "lab rats."
But there's no denying.
Trial subjects are using their own safety to conduct trials for many patients, all for the sake of allowing more people to use drugs safely!
In ancient times, there was Shennong who tasted a hundred herbs.
Today, there are professional trial subjects.
"Beep!"
"Beep!"
Two WeChat notification sounds rang out.
Shen Yan and Wu Hao simultaneously looked at their phone group chats.
The group chat information was the latest trial information posted by the group leader.
【The Artificial Blood Research Group at Gusu University is recruiting 20 trial subjects!】
Network information: Nationwide networking, physical information is entered into the national clinical trial system.
Trial field: Hematology.
Trial location: Gusu University Affiliated First Hospital.
Fee compensation: Cash payment of 20,000 yuan on the day of discharge, 2,000 yuan in cash at the end of each follow-up visit, 20,000 yuan paid by finance after the last follow-up visit, totaling 50,000 yuan.
Time arrangement: Antibody test on July 3rd, physical examination on July 4th, trial period of three weeks, discharge on July 26th.
Follow-up arrangement: August 4th, August 11th, August 18th, August 25th, August 31st.
Selection criteria:
1. Age 18-50 years old, both genders.
2. Body mass index (BMI) between 19～27 kg/m (including boundary values).
3. Smoking test is required for this project, only individuals who have never smoked.
4. Do not disturb if you have poor compliance, no-shows are not allowed, individuals with low character are not allowed.
Project note: During the trial process, if any aftereffects or adverse reactions occur, they will be treated free of charge at Gusu University Affiliated First Hospital!
After reading the detailed trial information.
Shen Yan and Wu Hao looked at each other, both somewhat surprised.
In previous trial processes.
Hospitals or research institutions would not be responsible for treating aftereffects!
Moreover, the Gusu University Artificial Blood Research Group offers very generous compensation for trial subjects.
Shen Yan immediately decided: "Wu Hao, I'm going to participate in the trial at Gusu University Affiliated First Hospital, what about you?"
"Of course!"
Wu Hao smiled and nodded.
...
July 5th.
Gusu University Affiliated First Hospital.
Inside a certain ward.
Shen Yan and Wu Hao were each playing with their phones.
The ward they were in was quite nice.
The ward has a separate bathroom, where they can shower.
They eat a balanced nutritional diet, and can also play with their phones.
This trial lasts for three weeks.
Every day, there are intensive blood draws and injections of artificial blood.
After the injection, first, 4 ml of blood is drawn for 15 minutes, then the interval is gradually extended, to half an hour, one hour, two hours...
The medical staff draw blood for testing using the pre-implanted needles on the trial subjects' arms.
Not only that.
The trial subjects can also visit each other, play chess and cards, and go for walks in the activity room.
They can even choose to withdraw from the trial midway!
Shen Yan put down his phone and said: "Wu Hao, what do you think of the Gusu University Artificial Blood Research Group?"
"Uh... I think they're very rich!"
Wu Hao pondered for a moment: "As far as I know, the head of their research group is Professor Chen Yu, the hottest name in the medical department at Gusu University this year.
The school allocated 50 million yuan in research funds to him, so their research group is flush with cash.
They also pay trial subjects a very high fee."
Hearing this, Shen Yan nodded in agreement.
The country stipulates that drugs must go through a series of clinical trials before they can be marketed.
Phase I clinical trials use healthy volunteers as the main subjects to study the body's response to the new drug and its tolerance, explore safe and effective dosages, and conduct research on the drug's pharmacokinetics in the body, including its absorption, distribution, and metabolism.
Phase II clinical trials require hundreds or thousands of volunteers, mainly to examine the drug's efficacy, the relationship between dosage and efficacy, and to further observe the drug's safety.
Phase III clinical trials require hundreds or thousands of volunteers to test the drug's safety again and observe its efficacy.
Generally speaking.
Trial subjects participate in Phase I.
If the trial subjects participating in Phase I clinical trials have no problems, Phase II and Phase III clinical trials for patients with the corresponding condition will be carried out.
Each stage of the trial has its own specific goals and subject group.
Through these clinical trials, the safety and efficacy of new drugs can be ensured, providing patients with better treatment options and hope.
The compensation for different drug trials also varies.
Relatively speaking.
Drugs for intractable diseases have higher compensation.
Wu Hao is already familiar with these basic processes.
Shen Yan said solemnly: "Before I became a professional trial subject, I didn't know much about the medical industry.
Later, I learned that the contraindications, dosages, and so on written on the instructions for the drugs you buy at pharmacies are all tested by trial subjects.
For example, the instructions say that pregnant women and elderly patients should not use the drug.
This is because there have indeed been cases of pregnant women and elderly patients using the drug and experiencing adverse reactions, which is why it's written on the instructions.
I've also heard that a trial subject developed facial paralysis, weight gain, and ichthyosis as aftereffects.
Therefore, trial subjects use their lives to make money and live precariously.
Hearing this.
Wu Hao nodded slightly.
Trial subjects get money, but they have to bear many aftereffects.
He said with a smile: "Ordinary institutions don't care about trial subjects after the trial is over.
But the Gusu University Artificial Blood Research Group has us sign a consent form.
It clearly states that Gusu University Affiliated First Hospital is fully responsible for any possible adverse drug reactions.
This is really very conscientious!"
"That's right!"
Shen Yan praised: "Professor Chen Yu, the head of the research group, has a very big picture.
If he needs to find people for the trial again next time.
I'm willing to be a trial subject for Professor Chen's research group again!"
"I'm willing too!"
Wu Hao smiled slightly.
He knows that this time the trial is for artificial blood.
Once the drug is successfully marketed, it will completely alleviate the blood shortage in the medical community in the future!